RT Journal Article SR Electronic T1 Statin therapy in patients with community-acquired pneumonia JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 403 OP 407 DO 10.7861/clinmedicine.17-5-403 VO 17 IS 5 A1 Frances S Grudzinska A1 Davinder PS Dosanjh A1 Dhruv Parekh A1 Rachel CA Dancer A1 Jaimin Patel A1 Peter Nightingale A1 Georgia M Walton A1 Elizabeth Sapey A1 David R Thickett YR 2017 UL http://www.rcpjournals.org/content/17/5/403.abstract AB Community-acquired pneumonia (CAP) is the leading cause of death from infection in developed countries. There is evidence of an association between improved survival from infection and statin use. The possible beneficial effects of statins are complicated by the common use of macrolide antibiotics for pneumonia, with current guidance suggesting that concurrent macrolide and statin use is contraindicated.We conducted an observational study of statin use in patients with CAP. Of 2,067 patients with CAP, 30.4% were on statin therapy at admission. Statin users were more likely to survive the admission (p<0.001). In addition, we conducted a survey of doctors and found that knowledge regarding concurrent macrolide and statin use was lacking.These data suggest a potential role of statins in the management of CAP. Further research using high-dose statins is required to assess their safe use in subjects with mild to moderate infections.