PT  - JOURNAL ARTICLE
AU  - Robert Tidswell
AU  - Mervyn Singer
TI  - Sepsis – thoughtful management for the non-expert
AID  - 10.7861/clinmedicine.18-1-62
DP  - 2018 Feb 01
TA  - Clinical Medicine
PG  - 62--68
VI  - 18
IP  - 1
4099  - http://www.rcpjournals.org/content/18/1/62.short
4100  - http://www.rcpjournals.org/content/18/1/62.full
SO  - Clin Med2018 Feb 01; 18
AB  - Sepsis is a common and often devastating medical emergency with a high mortality rate and, in many survivors, long-term morbidity. It is defined as the dysregulated host response to infection resulting in organ dysfunction, and its incidence is increasing as the population ages. However, it is a treatable and potentially reversible condition, especially if identified and treated promptly. A sound understanding of sepsis is crucial for optimal care. Although general guidelines are available for management, here we provide a foundation of understanding to encourage thoughtful, personalised management of sepsis during the acute phase. We provide an overview of the epidemiology, the new Sepsis-3 definitions, pathophysiology, clinical presentations, and investigation and management of sepsis for the non-expert.