PT - JOURNAL ARTICLE AU - Clare Webb AU - Alan Norris AU - Katie Hands TI - An acute transfusion reaction AID - 10.7861/clinmedicine.18-1-95 DP - 2018 Feb 01 TA - Clinical Medicine PG - 95--97 VI - 18 IP - 1 4099 - http://www.rcpjournals.org/content/18/1/95.short 4100 - http://www.rcpjournals.org/content/18/1/95.full SO - Clin Med2018 Feb 01; 18 AB - We present the case of a 67-year-old man who suffered an acute anaphylactic reaction during red cell transfusion due to the presence of anti-IgA antibodies. The incidence and clinical relevance of anti-IgA antibodies in IgA deficiency is reviewed, and the wider investigation and management of acute transfusion reactions is also discussed. This case highlights the need to consider the potential risks of blood component transfusion against the purported benefit.