RT Journal Article SR Electronic T1 An acute transfusion reaction JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 95 OP 97 DO 10.7861/clinmedicine.18-1-95 VO 18 IS 1 A1 Clare Webb A1 Alan Norris A1 Katie Hands YR 2018 UL http://www.rcpjournals.org/content/18/1/95.abstract AB We present the case of a 67-year-old man who suffered an acute anaphylactic reaction during red cell transfusion due to the presence of anti-IgA antibodies. The incidence and clinical relevance of anti-IgA antibodies in IgA deficiency is reviewed, and the wider investigation and management of acute transfusion reactions is also discussed. This case highlights the need to consider the potential risks of blood component transfusion against the purported benefit.