PT  - JOURNAL ARTICLE
AU  - Melanie J Davies
TI  - The prevention of type 2 diabetes mellitus
AID  - 10.7861/clinmedicine.3-5-470
DP  - 2003 Sep 01
TA  - Clinical Medicine
PG  - 470--474
VI  - 3
IP  - 5
4099  - http://www.rcpjournals.org/content/3/5/470.short
4100  - http://www.rcpjournals.org/content/3/5/470.full
SO  - Clin Med2003 Sep 01; 3
AB  - There is a worldwide epidemic of type 2 diabetes, with numbers predicted to reach over 210 million by the year 2010. Important risk factors for type 2 diabetes are obesity, physical inactivity and dietary factors. Recent evidence shows that type 2 diabetes can certainly be delayed, and possibly prevented, by intensive lifestyle intervention, and therapies including acarbose, metformin, orlistat and the glitazones in selected populations. However, the UK has not had a successful record in trials which aim to prevent diabetes, and therefore implementation of effective and successful intensive lifestyle intervention to prevent diabetes may prove difficult in the UK. Other ‘non-glucose lowering’ agents, such as statins, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, may have a role to play in the prevention of diabetes.