TY - JOUR T1 - Lesson of the month 2: An unusual adverse reaction associated with pramipexole JF - Clinical Medicine JO - Clin Med SP - 259 LP - 260 DO - 10.7861/clinmedicine.18-3-259 VL - 18 IS - 3 AU - Yasmina Tashkent AU - Vinod Aiyappan Y1 - 2018/06/01 UR - http://www.rcpjournals.org/content/18/3/259.abstract N2 - Dopamine agonists such as pramipexole are commonly used in the treatment of restless legs syndrome (RLS) as well as Parkinson's disease. Pramipexole's common side effects are well documented; however, adverse skin reactions are less well known. In this case, a 45-year-old male farmer presented with excessive daytime tiredness and reported a history suggestive of RLS. He was initiated on pramipexole but developed a maculopapular erythematous rash in sun-exposed areas 8 days after its commencement. The skin rash resolved following pramipexole's cessation and it is thought the patient experienced a drug-induced photosensitivity reaction to pramipexole. This case highlights the potential for photosensitivity reactions to pramipexole, which is especially significant in countries like Australia where UV solar radiation is especially high. ER -