RT Journal Article SR Electronic T1 Lesson of the month 2: An unusual adverse reaction associated with pramipexole JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 259 OP 260 DO 10.7861/clinmedicine.18-3-259 VO 18 IS 3 A1 Yasmina Tashkent A1 Vinod Aiyappan YR 2018 UL http://www.rcpjournals.org/content/18/3/259.abstract AB Dopamine agonists such as pramipexole are commonly used in the treatment of restless legs syndrome (RLS) as well as Parkinson's disease. Pramipexole's common side effects are well documented; however, adverse skin reactions are less well known. In this case, a 45-year-old male farmer presented with excessive daytime tiredness and reported a history suggestive of RLS. He was initiated on pramipexole but developed a maculopapular erythematous rash in sun-exposed areas 8 days after its commencement. The skin rash resolved following pramipexole's cessation and it is thought the patient experienced a drug-induced photosensitivity reaction to pramipexole. This case highlights the potential for photosensitivity reactions to pramipexole, which is especially significant in countries like Australia where UV solar radiation is especially high.