PT  - JOURNAL ARTICLE
AU  - Benjamin H Mullish
AU  - Horace RT Williams
TI  - <em>Clostridium difficile</em> infection and antibiotic-associated diarrhoea
AID  - 10.7861/clinmedicine.18-3-237
DP  - 2018 Jun 01
TA  - Clinical Medicine
PG  - 237--241
VI  - 18
IP  - 3
4099  - http://www.rcpjournals.org/content/18/3/237.short
4100  - http://www.rcpjournals.org/content/18/3/237.full
SO  - Clin Med2018 Jun 01; 18
AB  - Antibiotic-associated diarrhoea is among the most common adverse events related to antibiotic use. Most cases are mild, but Clostridium difficile infection causes a spectrum of disease, ranging from occasional diarrhoea to colitis, toxic megacolon, and potentially death. Recent developments in our understanding of the biology of the gut microbiota have provided new insights into the pathogenesis of these conditions, and have revealed a role for manipulation of the gut microbiota as a novel therapeutic approach. This review will give an overview of the assessment of these conditions, before focusing on the rapidly developing area of their treatment.