TY - JOUR T1 - <em>Clostridium difficile</em> infection and antibiotic-associated diarrhoea JF - Clinical Medicine JO - Clin Med SP - 237 LP - 241 DO - 10.7861/clinmedicine.18-3-237 VL - 18 IS - 3 AU - Benjamin H Mullish AU - Horace RT Williams Y1 - 2018/06/01 UR - http://www.rcpjournals.org/content/18/3/237.abstract N2 - Antibiotic-associated diarrhoea is among the most common adverse events related to antibiotic use. Most cases are mild, but Clostridium difficile infection causes a spectrum of disease, ranging from occasional diarrhoea to colitis, toxic megacolon, and potentially death. Recent developments in our understanding of the biology of the gut microbiota have provided new insights into the pathogenesis of these conditions, and have revealed a role for manipulation of the gut microbiota as a novel therapeutic approach. This review will give an overview of the assessment of these conditions, before focusing on the rapidly developing area of their treatment. ER -