TY - JOUR T1 - Lesson of the month 2: An unusual cause of depression in an older man: Cushing’s syndrome resulting from metastatic small cell cancer of the prostate JF - Clinical Medicine JO - Clin Med SP - 432 LP - 434 DO - 10.7861/clinmedicine.18-5-432 VL - 18 IS - 5 AU - Paul Kleinig AU - Patrick Russell Y1 - 2018/10/01 UR - http://www.rcpjournals.org/content/18/5/432.abstract N2 - This article describes the case of an older patient whose main presenting problem was depression. A constellation of clinical and biochemical features led to a search for medical causes of his low mood, which uncovered ectopic adrenocorticotropic hormone (ACTH) secretion. Post-mortem examination showed that the source of ACTH was small cell neuroendocrine carcinoma of the prostate, and that the patient had died from the sequelae of profound immune suppression. ER -