%0 Journal Article %A Paul Kleinig %A Patrick Russell %T Lesson of the month 2: An unusual cause of depression in an older man: Cushing’s syndrome resulting from metastatic small cell cancer of the prostate %D 2018 %R 10.7861/clinmedicine.18-5-432 %J Clinical Medicine %P 432-434 %V 18 %N 5 %X This article describes the case of an older patient whose main presenting problem was depression. A constellation of clinical and biochemical features led to a search for medical causes of his low mood, which uncovered ectopic adrenocorticotropic hormone (ACTH) secretion. Post-mortem examination showed that the source of ACTH was small cell neuroendocrine carcinoma of the prostate, and that the patient had died from the sequelae of profound immune suppression. %U https://www.rcpjournals.org/content/clinmedicine/18/5/432.full.pdf