TY - JOUR T1 - Immunoglobulin use in immune deficiency in the UK: a report of the UKPID and National Immunoglobulin Databases JF - Clinical Medicine JO - Clin Med SP - 364 LP - 370 DO - 10.7861/clinmedicine.18-5-364 VL - 18 IS - 5 AU - Ben Shillitoe AU - Rob Hollingsworth AU - Mark Foster AU - Tomaz Garcez AU - David Guzman AU - J David Edgar AU - Matthew Buckland Y1 - 2018/10/01 UR - http://www.rcpjournals.org/content/18/5/364.abstract N2 - Supply of immunoglobulin in the UK faces pressures due to increasing demand, cost and variable supply. This paper describes immunoglobulin replacement therapy (IGRT) in primary immunodeficiency (PID) and secondary immunodeficiency (SID) to assist in the ongoing planning of UK immunoglobulin provision. A retrospective analysis of the National Immunoglobulin Database and the UKPID registry was carried out. In total, 3,222 patients are registered as receiving IGRT for immunodeficiencies. Predominately antibody disorders made up the largest diagnostic category (61% of patients). The total cost of IGRT for immunodeficiency for 2015/16 was £40,673,350; an average annual cost of £1,099,254 per centre and £12,124 per PID patient. SCIg accounted for 43.8% and 50.1% of IGRT, with home therapy accounting for 42.7% and 57.5% of place of therapy in the National Immunoglobulin Database and UKPID registry respectively. In 2015/16 use of immunoglobulin in SID increased by 24% over the previous financial year. The overall trends of increasing demand in immunology are mirrored in other specialties, most notably neurology and haematology. These data are the first national overview of IGRT for immunodeficiencies, providing a valuable resource for clinicians and policy makers in the ongoing management of UK immunoglobulin supply. ER -