RT Journal Article SR Electronic T1 Breathlessness in liver disease: A case of hepatopulmonary syndrome  JF Clinical Medicine JO Clin Med FD Royal College of Physicians SP 250 OP 251 DO 10.7861/clinmedicine.19-3-250 VO 19 IS 3 A1 Ruth Porther A1 Gavin Ross A1 Subramaniam Nagasayi YR 2019 UL http://www.rcpjournals.org/content/19/3/250.abstract AB Hepatopulmonary syndrome (HPS) is often not considered as a cause of breathlessness in patients with liver cirrhosis. It consists of a triad of liver disease, intrapulmonary shunting and hypoxaemia. Here we discuss HPS in a patient presenting with acute on chronic breathlessness and typical features of orthodeoxia and platypnoea. Evidence of intrapulmonary shunting on imaging was essential to making the diagnosis, which carries a poor prognosis and was an urgent indication for liver transplantation.