RT Journal Article
SR Electronic
T1 Lessons of the month 3: Gone but not forgotten – Osler – a reminder of the syndrome not bearing his name
JF Clinical Medicine
JO Clin Med
FD Royal College of Physicians
SP 523
OP 525
DO 10.7861/clinmed.2019.0253
VO 19
IS 6
A1 Amit KJ Mandal
A1 Bashir Mohamad
A1 Constantinos G Missouris
YR 2019
UL http://www.rcpjournals.org/content/19/6/523.abstract
AB Streptococcus pneumoniae is the most frequently implicated microbial agent in community acquired bacterial pneumonia and meningitis. It is also responsible for between 1 and 3% of cases of native valve infective endocarditis, with mortality rates up to 60%. Osler first described the association between pneumococcal pneumonia, endocarditis, and meningitis secondary to bacteria that he described as ‘micrococci’, subsequently elucidated to be S pneumoniae by Robert Austrian, and the syndrome bears his name. We report a case of fulminant pneumococcal native aortic valve endocarditis and perforation in a young male patient with chronic alcoholism and splenectomy who exhibited poor compliance to pneumococcal prophylaxis.