Recommended treatment regimens for common causes of endocarditis
| Organism | Native valve | Prosthetic valve |
|---|---|---|
| Staphylococcus aureus (methicillin sensitive) | Flucloxacillin 2 g, 4–6 hourly | Flucloxacillin 2 g, 4–6 hourly, and rifampicin 450–600 mg, bd, and gentamicin 1 mg/kg, bd (latter for 2–6 weeks) |
| Staphylococcus aureus (methicillin resistant) | Vancomycin (dose weight-based) | Vancomycin (dose weight-based), and rifampicin 450–600 mg, bd, and gentamicin 1 mg/kg, bd (latter for 2–6 weeks) |
| Viridans group streptococci and Streptococcus bovis group | Benzyl penicillin 1.2 g, 4 hourly; or
ceftriaxone 2 g, once a day (od); or benzyl penicillin 1.2 g, 4 hourly and gentamicin 1 mg/kg, twice a day (bd; both for two weeks) | Benzyl penicillin 1.2 g, 4 hourly; or
ceftriaxone 2 g, od |
| Enterococcus faecalis | Amoxicillin 2 g, 4 hourly, and gentamicin 1 mg/kg, bd or ceftriaxone 2 g, bd | Amoxicillin 2 g, 4 hourly, and gentamicin 1 mg/kg, bd or ceftriaxone 2 g, bd |