Table 1.

Contrasting features of different causes of thrombotic microangiopathy

FeatureSTEC-HUSTTPComplement-mediated aHUS
Presentation1–2 weeks after colitis-like illnessProminent neurological symptomsMay have personal or family history of TMA
Laboratory testsAKI predominatesSevere thrombocytopeniaAKI predominates
Diagnostic testStool culture STEC PCRADAMTS13 activity levelGenetic and autoantibody screening
TreatmentSupportiveEmergency plasma exchange, corticosteroidsEculizumab
  • aHUS = atypical haemolytic uraemic syndrome; AKI = acute kidney injury; HUS = haemolytic uraemic syndrome; PCR = polymerase chain reaction; STEC = Shiga toxin-producing Escherichia coli; TMA = thrombotic microangiopathy; TTP = thrombotic thrombocytopenic purpura.