Authors | n | Intervention (respiratory device) | Setting | Outcome | Key results | Strengths | Limitations |
---|---|---|---|---|---|---|---|
Scaravilli et al, 201533 | 15 | Prone episodes, 1–3 per patient with duration 2–4 hours (longest 8 hours) Oxygen facemasks, CPAP and HFNC) | ICU (ARDS) | Change in PaO2/FiO2 from supine to prone position, then return to supine | PaO2/FiO2 (kPa) 11.9±3.7 to 16.5±7.1* (returning to 12.1±5.6)* | Measured response to re-supination after 6–8 hours | Respiratory device the same over prone episode in only 18/43 |
Ding et al, 202034 | 20 | Protocolised trials of HFNC or CPAP/BiPAP +/− prone positioning | ICU (ARDS) | Intubation rate Change in PaO2/FiO2 from supine to prone position | 55% intubated (expected 75%) PaO2/FiO2 (kPa) 12.7±2.9 to 17.3±4.7 kPa† (those who avoided intubation) | Meaningful primary outcome Suggests benefit in moderate ARDS or varying aetiology | Complex protocol with combination of interventions unachievable on wards Results for success and failure groups reported separately |
Valter et al, 200335 | 4 | Single episode of prone positioning, duration 50 minutes to 5 hours (CPAP/BiPAP used pre-prone positioning in n=3) | ICU (ARF) | Change in PaO2/FiO2 from supine to prone position | PaO2/FiO2 (kPa) 11.9 to 24.7 (mean values) | Small case series | |
Bellone and Basile, 201836 | 3 | Repeated episodes of prone positioning for 6 hrs/day (HFNC during prone positioning) | Emergency ward (ARF) | Change in PaO2/FiO2 from supine to prone position | PaO2/FiO2 (kPa) 15.7 to 36.7 (1 day of intervention) to 40.4 (9 days of intervention | Suggests improvement with sustained use of prone positioning | Small case series |
ARF = acute respiratory failure; BiPAP = bilevel positive airway pressure; CPAP = continuous positive airway pressure; ED = emergency department; HFNC = high flow nasal cannula; ICU = intensive care unit. *p<0.05 from preceding intervention. †p=0.016, HFNC to HFNC + prone.