Table 1.

Options for the medical management of cholestatic pruritis

Cholestyramine4 g/day to a maximum of 16 g/day as requiredAdministration requires adequate spacing to avoid affecting the absorption of other medications
Rifampicin300–600 mg/dayNeeds careful monitoring of LFTs; small risk of hepatotoxicity
Naltrexone50 mg/dayCareful dosing required to avoid opioid withdrawal side effects
Sertraline100 mg/day
Gabapentin300 mg/day, dose titrate as normal
  • LFTs = liver function tests.