Options for the medical management of cholestatic pruritis
| Pharmacotherapy | Dose | Notes |
|---|---|---|
| Cholestyramine | 4 g/day to a maximum of 16 g/day as required | Administration requires adequate spacing to avoid affecting the absorption of other medications |
| Rifampicin | 300–600 mg/day | Needs careful monitoring of LFTs; small risk of hepatotoxicity |
| Naltrexone | 50 mg/day | Careful dosing required to avoid opioid withdrawal side effects |
| Sertraline | 100 mg/day | |
| Gabapentin | 300 mg/day, dose titrate as normal |
LFTs = liver function tests.