Service factors in patients with pancreatic exocrine insufficiency, and results of adjusted univariable analysis of their association with initiation of PERT and clinical response
| Service factor | Patients with PEI | Association with initiation of PERT, OR (95% CI)a | Association with clinical response to PERT, OR (95% CI)a |
|---|---|---|---|
| FE1 result, n=182, mean (SD) | 92.9 (93.2) | 1.00 (0.99–1.00) | 1.00 (0.99–1.01) |
| FE1 repeated, n=182, n (%) | 42 (23.1) | 3.06 (1.38–6.77)b | 0.50 (0.14–1.75) |
| Pancreatic imaging performed, n=182, n (%) | 149 (81.9) | 2.53 (1.14–5.60)b | 0.44 (0.05–4.13) |
| Abnormal pancreatic imaging, n=143, n (%) | 67 (46.9) | 2.50 (1.20–5.25)b | 10.70 (1.62–70.70)b |
| Nutritional blood tests performed, n=182, n (%) | 124 (68.1) | 1.71 (0.90–3.25) | 2.50 (0.73–8.60) |
| Abnormal nutrition blood tests, n=124, n (%) | 65 (52.4) | 2.08 (1.07–4.04)b | 3.62 (0.87–15.10) |
| PERT prescribed, n=182, n (%) | 103 (56.6) | n/a | n/a |
| Starting dose of PERT, median (IQR), IU/meal | 50,000 (0) | n/a | 1.01 (0.98–1.05) |
| Dietitian referral, n=182, n (%) | 77 (42.3) | n/a | 0.92 (0.22–3.86) |
| Followed up, n=182, n (%) | 99 (54.4) | n/a | 0.70 (0.08–6.40) |
| Clinical response to PERT, n=81, n (%) | 67 (82.7) | n/a | n/a |
Reference categories for alcohol excess and smoking are ‘never’.
↵a = adjusted for age, sex and ethnicity;
↵b = p<0.05; CI = confidence interval; FE1 = faecal elastase-1; GI = gastrointestinal; IQR = interquartile range; n/a = not applicable; OR = odds ratio; PEI = pancreatic exocrine insufficiency; PERT = pancreatic enzyme replacement therapy; SD = standard deviation.