Royal College of Paediatrics and Child Health paediatric inflammatory multisystem disorder – temporarily associated with SARS-CoV-2 diagnostic criteria6
| Imaging and ECG | Clinical | Laboratory |
|---|---|---|
| ECHO and ECG: Coronary artery dilatation Myocarditis Pericardial effusion Valvulitis CXR: Patchy symmetrical infiltrates Pleural effusion Abdominal US: Ascites Colitis Hepatosplenomegaly Ileitis Lymphadenopathy Chest CT: Patchy symmetrical infiltrates Pleural effusion (May demonstrate coronary artery abnormalities if with contrast) | All: Persistent fever>38.5°C Most: Hypotension Oxygen requirement Some: Abdominal pain Confusion Conjunctivitis Cough Diarrhoea Headache Lymphadenopathy Mucus membrane changes Neck swelling Rash Respiratory symptoms Sore throat Swollen hands and feet Syncope Vomiting | All: Abnormal fibrinogen Absence of potential causative organisms (other than SARS-CoV-2) High CRP High D-dimers High ferritin Hypoalbuminemia Lymphopenia Neutrophilia in most – normal neutrophils in some Some: Acute kidney injury Anaemia Coagulopathy High IL-6a High IL-10a Neutrophilia Proteinuria Raised CK Raised LDH Raised triglycerides Raised troponin Thrombocytopenia Transaminitis |
↵a = these assays are not widely available, CRP can be used as a surrogate marker for IL-6; CK = creatinine kinase; CRP = C-reactive protein; CT = computed tomography; CXR = chest X-ray; ECG = electrocardiography; ECHO = echocardiography; IL = interleukin; LDH = lactate dehydrogenase; PCR = polymerase chain reaction; PIMS-TS = paediatric inflammatory multisystem syndrome – temporally associated with SARS-CoV-2; RCPCH = Royal College of Paediatrics and Child Health; US = ultrasound.