Table 1.

Predictors of major cardiovascular events

	Univariate analysis	Multivariate analysis
	p value	OR (95% CI)	p value
Age at listing	0.18
Male^a	0.007	9.98 (1.20–82.92)	0.03
BMI at first year of transplantation	0.20
Aetiology of liver disease	0.34
Pre-transplant DM^a	0.049	3.11 (0.92–10.57)	0.07
Pre-transplant hypertension	0.46
Pre-transplant dyslipidaemia	0.63
Pre-transplant CVE	0.71
History of smoking	0.33
Post-transplant DM	0.15
Post-transplant hypertension^a	0.0007	1.47 (0.42–5.16)	0.55
Post-transplant dyslipidaemia^a	<0.0001	21.71 (5.52–85.36)	<0.0001^c
Use of tacrolimus^a	0.07	1.28 (0.21–7.77)	0.79
Use of cyclosporin^a	0.002	6.37 (0.94–43.33)	0.06
Use of sirolimus	0.53
Centre (Nottingham/Ottawa)^b	0.13	0.53 (0.12–2.31)	0.40

↵^a = parameters with a p-value <0.10 on univariate analysis were included in the multivariate analysis
↵^b = variable ‘centre’ was forced to be included in the multivariate analysis
↵^c = the Bonferroni-corrected level of significance in this analysis was p<0.007; BMI = body mass index; CI = confidence interval; CVE = cardiovascular event; DM = diabetes mellitus; OR = odds ratio.