Disease | Administration method | Duration | Outcome | Research design |
---|---|---|---|---|
NAFLD | Drink HRW | 4 weeks | ↓ fat accumulation | Randomised controlled pilot trial |
CHB | Drink HRW 3x daily (1,200–1,800 mL) | 6 weeks | Improve tendencies in liver function and HBV DNA level | Randomised controlled study |
Liver dysfunction caused by tumour | Drink HRW (0.55–0.65 mM) | 6 weeks | QOL scores significantly improved | Randomised, placebo-controlled study |
Liver dysfunction after colorectal cancer chemotherapy | Drink 1,000 mL HRW, 1 day prior to chemotherapy until the end | 4 days | Placebo group: significantly ↑ ALT, AST, IBIL. Experimental group: no differences | Randomised, placebo-controlled study |
Liver cancer with radiofrequency ablation | 5 mL/kg HRW (>0.6 mmol/L) 4 hours before operation | Once | Improves anti-inflammatory ability: ↓ HMGB1, VEGF1; ↑ IL-4, IL-10 | Randomised controlled study |
Liver injury in patients with initial treatment of pulmonary tuberculosis | Drink hydrogen-saturated water | 2, 4 and 6 weeks | In 4 and 6 weeks, ↓ XOD, MDA; ↑ SOD, GSTReduce drug-induced liver injury | Controlled trial |
ALT = alanine aminotransferase; AST = aspartate aminotransferase; CHB = chronic hepatitis B; GST = glutathione S-transferase; HBV = hepatitis B virus; HMGB1 = high-mobility group box 1; HRW = hydrogen-rich water; IBIL = indirect bilirubin; IL = interleukin; MDA = malondialdehyde; NAFLD = non-alcoholic fatty liver disease; QOL = quality of life; SOD = superoxide dismutase; VEGF1 = vascular endothelial growth factor 1; XOD = xanthine oxidase.