Contributing factors to impaired cardiorespiratory function in COVID-19 patients
Infection
viral
bacterial
fungal.
Left heart dysfunction/rhythm disturbances.
Hyper-/hypovolaemia.
Thrombosis
in situ
embolic.
Immunological response (humoral and cellular).
Right heart dysfunction.
Myocarditis.
Pulmonary hypertension
hypoxia
vasoconstriction
thrombosis
vascular remodelling
acute lung injury with loss of gas transfer area
pre-existing conditions.
Pre-morbid cardiorespiratory diseases and medication.
Evolving pulmonary fibrosis.
Current medical comorbidities eg other organ dysfunction.
Consequences of mechanical ventilatory support.