Table 1.

Profiles and medicinal forms of some common insulins used in the UK

Human synthetic insulin
Short acting
  • Absorbed quickly and lasts for several hours

  • Onset 30–45 minutes, peak 2–4 hours and duration up to 6 hours

  • Eg Humulin S, Humulin R and Actrapid

Intermediate acting / isophane
  • Absorbed slowly and lasts for up to 24 hours

  • Onset 1–2 hours, peak 4–8 hours and duration 16–18 hours

  • Eg Insulatard, Humulin I and Insuman Basal

Fixed mixtures / pre-mixed
  • Mixture of short- and intermediate-acting insulin (biphasic human insulin)

  • Onset 30–45 minutes, peak 2–4 hours and duration 14–16 hours

  • Eg Humulin M3, Insuman Comb 15 and Insuman Comb 50

Analogue insulin
Rapid acting
  • Absorbed more rapidly and with shorter duration than the short-acting insulin

  • Onset 10–20 minutes, peak 1–3 hours and duration 3–5 hours

  • Eg NovoRapid (aspart), Humalog (lispro) and Apidra (glulisine)

Ultra-rapid acting
  • More rapid than rapid-acting insulin

  • Onset 4 minutes

  • Eg Fiasp (aspart)

Long acting
  • Absorbed slower than intermediate insulin providing a flatter profile

  • Onset 1–2 hours, no peak and duration up to 24 hours

  • Eg Levemir (detemir), Lantus (glargine), and Abasaglar and Semglee (glargine biosimilars)

Ultra-long acting
  • Absorbed slower than intermediate insulin providing a flatter profile

  • Onset 1–2 hours, no peak and duration 36–42 hours

  • Eg Tresiba (degludec), Toujeo (glargine 300 units/mL)

Fixed mixtures / pre-mixed
  • Mixture of rapid- and intermediate-acting insulin

  • Onset 15 minutes, peak 50–90 minutes and duration 14–16 hours

  • eg NovoMix 30, Humalog Mix 25 and Humalog Mix 50