Six or more of the following features in the absence of another explanation: Vomiting Abdominal pain Polydipsia/polyuria Encephalopathy High bilirubin (>14 μmol/L) Hypoglycaemia (<4 mmol/L) High uric acid (>340 μmol/L) Leucocytosis (>11 × 106/L) Ascites or bright liver on ultrasound High AST/ALT (>42 IU/L) High ammonia (>47 μmol/L) Renal impairment (creatinine >150 μmol/L) Coagulopathy (PT >14 seconds or APTT >34 seconds) Microvesicular steatosis on liver biopsy |
ALT = alanine aminotransferase; APTT = activated partial thromboplastin time; AST = aspartate aminotransferase; PT = prothrombin time.