Table 1.

HScore and %HScore algorithm

ParameterHScore points (criteria)%HScore points (criteria) (Minimum variables 3)
Temperature (°C)0 (<38.4),
33 (38.4–39.4),
or 49 (>39.4)
0 (<38.4),
33 (38.4–39.4),
or 49 (>39.4)
No of cytopenias*0 (one lineage),
24 (two lineages),
or 34 (three lineages)
0 (one lineage),
24 (two lineages), or 34 (three lineages)
Ferritin (mg/L)0 (<2,000),
35 (2,000–6,000),
or 50 (>6,000)
0 (<2,000),
35 (2,000–6,000), or 50 (>6,000)
Triglyceride (mmol/L)0 (<1.5), 44 (1.5–4),
or 64 (>4)
0 (<1.5), 44 (1.5–4),
or 64 (>4)
Fibrinogen (g/L)0 (>2.5) or
30 (≤2.5)
0 (>2.5) or
30 (≤2.5)
AST/ALT (IU/L)0 (<30) or 19 (≥30)0 (<30) or 19 (≥30)
Haemophagocytosis0 (no) or 35 (yes)
Immunosuppression0 (no) or 18 (yes)
Hepatomegaly / splenomegaly0 (none), 23 (either), or 38 (both)
ScoreSum of points above (maximum 337)Sum of points above / maximum score (maximum 100%)
  • *Haemoglobin ≤92 g/L and/or WBC ≤5 × 109/L and/or platelets ≤110 × 109/L.

  • Features on bone marrow aspirate. ALT = alanine aminotransferase; AST = aspartate transaminase; IU = international units.