Factors determining delirium in older patients (aged >65 years) with COVID-19 infection during inpatient admission
| Patients without delirium, n=504 | Patients with delirium, n=158 | p-value | Adjusted OR (95% CI) | |
|---|---|---|---|---|
| Age, median years (IQR) | 77 (71–84) | 82 (76–88) | p<0.001 | 1.05 (1.02–1.07) |
| Male, n (%) | 286 (56.7) | 94 (59.5) | ||
| Ethnicity, n (%) | ||||
| White | 185 (36.7) | 75 (47.5) | ||
| Asian | 51 (10.1) | 12 (7.6) | ||
| Black | 72 (14.3) | 21 (13.3) | ||
| Other | 179 (35.5) | 47 (29.7) | ||
| Not stated | 17 (3.4) | 3 (1.9) | ||
| Medical history | ||||
| Dementia (including suspected), n (%) | 95 (18.8) | 64 (40.5) | p<0.001 | 1.92 (1.24–2.99) |
| Clinical frailty score ≥5, n (%) | 238 (47.2) | 107 (67.7) | p<0.001 | 1.55 (1.01–2.38) |
| Hypertension, n (%) | 292 (57.9) | 106 (67.1) | p<0.05 | |
| Diabetes mellitus, n (%) | 194 (38.5) | 66 (41.8) | ||
| Ischaemic heart disease, n (%) | 113 (22.4) | 37 (23.4) | ||
| Chronic kidney disease, n (%) | 88 (17.5) | 33 (20.9) | ||
| Stroke/TIA, n (%) | 71 (14.1) | 30 (19.0) | ||
| Chronic respiratory disease, n (%) | 124 (24.6) | 33 (20.9) | ||
| Cancer, n (%) | 114 (22.6) | 31 (19.6) | ||
| Polypharmacy, n (%) | 327 (64.9) | 109 (69) | ||
| Factors related to admission | ||||
| Concurrent infection, n (%) | 223 (44.2) | 96 (60.8) | p<0.001 | 2.02 (1.38–2.96) |
| Clinical outcomes | ||||
| Mortality, n (%) | 213 (42.3) | 57 (36.1) | ||
| Length of admission, median days (IQR) | 9 (5–17) | 14 (8–30) | p<0.001 |
CI = confidence interval; IQR = interquartile range; OR = odds ratio; TIA = transient ischaemic attack.