Table 1.

Ability of severity scoring systems to stratify risk for 7-day mortality or early severe adverse event for COVID-19 pneumonia only

CURB65, n=1,708012345p value
 Number of cases, n3314314703669911
 ESAE, n (%)67 (20)133 (31)158 (34)154 (42)52 (53)7 (64)<0.001
Lac-CURB65, n=1,155LowModerateHigh
 Number of cases, n372407376
 ESAE, n (%)95 (26)130 (32)163 (43)<0.001
NEWS2, n=1,708LowModerateHigh
 Number of cases, n637385686
 ESAE, n (%)106 (17)131 (34)337 (49)<0.001
MuLBSTA score, n=1,042LowHigh
 Number of cases, n446596
 ESAE, n (%)112 (25)210 (35)<0.001
qSOFA score, n=1,7180123
 Number of cases, n55488325823
 ESAE, n (%)111 (20)336 (35)115 (45)13 (57)<0.001
  • Comparison of proportions were done using chi-squared test for trend. Lac-CURB65 cut-offs: low = CURB65 ≤1 and/or lactate <2.0 mmol/L; moderate = CURB65 2 and/or lactate 2.0–4.0 mmol/L; high = CURB65 ≥3 and/or lactate >4.0 mmol/L. NEWS2 score cut-offs: low = score 0–4; medium = score 5–6; high = aggregate score ≥7. CURB65 = confusion, urea nitrogen, respiratory rate, blood pressure and age of 65 years or older score; ESAE = early severe adverse event; Lac-CURB65 = lactate, confusion, urea nitrogen, respiratory rate, blood pressure and age of 65 years or older score; MuLBSTA = multilobular infiltration, hypo-lymphocytosis, bacterial coinfection, smoking history, hyper-tension and age score; NEWS2 = National Early Warning Score 2; qSOFA = quick Sequential (Sepsis-related) Organ Failure Assessment.