Performance characteristics of severity assessment tools to predict early severe adverse outcome in SARS-CoV-2 infection
| Sensitivity, % | Specificity, % | PPV, % | NPV, % | |
|---|---|---|---|---|
| CURB65 ≥2, n=1,353 | 66.00 | 48.51 | 33.20 | 78.63 |
| CURB65 ≥3, n=700 | 38.00 | 76.61 | 38.65 | 76.11 |
| Lac-CURB-65 ≥moderate, n=1,035 | 76.22 | 34.20 | 31.59 | 78.30 |
| Lac-CURB-65 high, n=489 | 43.36 | 71.84 | 38.04 | 76.08 |
| qSOFA ≥2, n=431 | 23.82 | 86.21 | 40.10 | 74.49 |
| NEWS2 ≥medium, n=1,349 | 80.12 | 50.75 | 38.84 | 86.73 |
| NEWS2 high, n=850 | 57.80 | 71.82 | 44.47 | 81.34 |
| MuLBSTA high, n=666 | 62.01 | 56.68 | 33.33 | 81.03 |
CURB65 = confusion, urea nitrogen, respiratory rate, blood pressure and age of 65 years or older score; Lac-CURB65 = lactate, confusion, urea nitrogen, respiratory rate, blood pressure and age of 65 years or older score; MuLBSTA = multilobular infiltration, hypo-lymphocytosis, bacterial coinfection, smoking history, hyper-tension and age score; NEWS2 = National Early Warning Score 2; NPV = negative predictive value; PPV = positive predictive value; qSOFA = quick Sequential (Sepsis-related) Organ Failure Assessment.