Table 1.

Differential diagnoses for thrombocytopenia

InfectionsHepatitis C, HIV, parvovirus B19, EBV, CMV, malaria, sepsis, DIC, Helicobacter pylori and other viral infections
Autoimmune/inflammatoryRheumatoid arthritis, SLE, antiphospholipid syndrome, ITP, TTP and haemolytic uraemic syndrome
Malignancy / bone marrow failureAplastic anaemia, lymphoma and acute leukaemias
Alcohol
Drug-relatedAntimalarials, chemotherapies, antibiotics (eg rifampicin and vancomycin), heparin and vaccine induced
EndocrineThyroid
PregnancyGestational thrombocytopenia, HELLP and ITP
DietaryB12/folate deficiencies
CongenitalCongenital thrombocytopenia
VascularVascular surgery / recent cardiopulmonary bypass
OtherParoxysmal nocturnal haematuria and Budd–Chiari syndrome
  • CMV = cytomegalovirus; DIC = disseminated intravascular coagulation; EBV = Epstein–Barr virus; HELLP = haemolysis, elevated liver enzymes and low platelets; ITP = immune thrombocytopenic purpura; SLE = systemic lupus erythematosus; TTP = thrombotic thrombocytopenic purpura.