A classification system for some examples of autoimmune haemolytic anaemia
| Warm AIHA | Cold AIHA (cold agglutinins) | Mixed AIHA | |
|---|---|---|---|
| Primary | IgG +/− C3 (mostly IgG) | C3/C3d (known as CHAD) | IgG + C3 |
| Secondary | IgG +/− C3 (mostly IgG) | C3/C3d | IgG + C3 |
| Secondary examples | Lymphoproliferative disorders | Lymphoproliferative disorders | Lymphoproliferative disorders |
| (eg CLL and NHL) | (eg NHL) | (eg NHL) | |
| Infections (eg CMV) | Infections (eg EBV) | Autoimmune disorders (eg SLE) | |
| Autoimmune disorders | Autoimmune disorders | ||
| (eg SLE) | (eg SLE) |
AIHA = autoimmune haemolytic anaemia; CHAD = cold haemagglutinin disease; CLL = chronic lymphocytic leukaemia; CMV = cytomegalovirus; EBV = Epstein–Barr virus; NHL = non-Hodgkin lymphoma; SLE = systemic lupus erythematosus.