Comparison of 21-hour and Scottish and Newcastle Anti-emetic Protocol treatment protocols (secondary outcomes)
| SNAP (n=76) | 21-hour (n=218) | ARR/ARI (95% CI) | |
|---|---|---|---|
| Anaphylactoid reaction, % | 5.3 | 15.4 | 0.10 (0.03–0.17)a |
| Mean duration of extended NAC infusion required, hoursb | 3.0 | 2.4 | – |
| Mean total duration of NAC infusion, hours | 15.0 | 23.4 | – |
↵aStatistically significant.
↵bThis is the mean time required for infusion across all treated patients, not solely those receiving extended infusions. ARI = absolute risk increase; ARR = absolute risk reduction; CI = confidence interval; NAC = N-acetylcysteine; SNAP = Scottish and Newcastle Anti-emetic Protocol.