Baseline characteristics
| SNAP (n=76) | 21-hour (n=218) | 21-hour vs SNAP p-value | |
|---|---|---|---|
| Age, years, median (IQR) | 30 (21–46), n=76 | 29 (21–46), n=218 | 0.99 |
| Female, % | 69.7, (n=218) | 67.9, (n=218) | 0.77 |
| Weight, kg, median (IQR) | 73.0 (60–82.5), n=69 | 72.3 (61.5–91.5), n=196 | 0.35 |
| Paracetamol dose ingested, mg/kg, median (IQR) | 241 (173–371), n=67 | 223 (133–326), n=181 | 0.09 |
| Single acute overdosea as a proportion of patients requiring treatment, % | 84.2 (n=75) | 83.2 (n=212) | 0.96 |
| Time from ingestion to NAC for single acute overdose, hours, median (IQR) | 8.0 (6.0-10.5), n=57 | 9.0 (7.0-12.0), n=143 | 0.02 |
↵aSingle acute overdose = ingestion of paracetamol over a period of 1 hour or less, as opposed to staggered overdose. P values obtained by Mann–Whitney U test, or test of proportions. n = number of patients for whom data were available for abstraction. IQR = interquartile range; NAC = N-acetylcysteine; SNAP = Scottish and Newcastle Anti-emetic Protocol.