Box 1.

Reasons for excluding potential donors who are considered at risk of transmitting Creutzfeldt–Jakob disease

People who have received a blood transfusion, tissue or organ transplant from a donor since 1980.
Anyone who has received human pituitary-derived hormones, grafts of human dura mater or cornea, sclera or other ocular tissue.
Members of a family at risk of inherited prion diseases.
People who have been notified that they might be at increased risk of variant Creutzfeldt–Jakob disease because of possible exposure to an infected individual from surgical instruments, a blood product transfusion or transplant of tissues or organs, or that their blood or tissues have developed a prion-related disorder.