Table 2.

Repeat measurements (symptoms, lung function tests and blood tests) and exercise test results

Measurement*Baseline3 months12 months
Symptoms
Breathlessness97.7% (43/44)59.6% (28/47)50.0% (22/44)
Cough88.4% (38/43)21.3% (10/47)20.0% (6/30)
Chest pain13.6% (6/44)17.0% (8/47)0.0% (0/29)
Exercise test results (3 months only)
Oxygen saturation (baseline) (%)97 (96–98), n=43
Oxygen saturation (lowest final) (%)95 (93–97), n=43
Change in modified Borg dyspnoea scale score2 (1–2), n=37
Change in oxygen saturation (%)–2 (–3 to 0), n=41
Test resultNo desaturation64.4% (29/45)
Desaturation31.1% (14/45)
Patient unable4.4% (2/45)
Lung function test results (3 months and 12 months only)
FEV1 (% predicted)84 (72–99), n=4493 (83–101), n=27
FVC (% predicted)81 (70–97), n=4588 (77–100), n=27
FEV1/FVC ratio111 (105–117), n=44107 (102–111), n=27
TLC (% predicted)72 (60–82), n=2579 (69–83), n=11
DLCO (% predicted)59 (53–67), n=2773 (63–77), n=22
SpirometryNormal55.6% (25/45)85.2% (23/27)
Restrictive42.2% (19/45)14.8% (4/27)
Obstructive2.2% (1/45)0.0% (0/27)
Bloods
Lymphocytes (3109/L)0.7 (0.5–1.1), n=451.9 (1.5–2.6), n=442.1 (1.6–2.6), n=26
CRP (mg/L)158 (103–294), n=452.1 (0.8–9.7), n=423.3 (0.9–8.3), n=20
D-dimer (μg/mL)2,435 (1,176–10,842), n=44323 (27–865), n=39373 (0–453), n=8
Ferritin (μg/L)1,116 (544–2,493), n=4282 (34–202), n=40226 (58–469), n=6
Troponin (ng/mL)8 (1–26), n=441 (1–3), n=391.5 (1–2), n=6
BNP (pg/mL)11 (1–51), n=3522 (1–56), n=381 (1–25), n=7
Creatinine (μmol/L)77 (63–125), n=5378 (65–96), n=4481 (65–116), n=32
Urea (μmol/L)10.3 (6.1–17.3), n=545.5 (4.4–7.0), n=426.1 (3.9–8.0), n=30
  • *D-dimer >20,000 μg/mL was replaced with 20,000 μg/mL, <270 μg/mL with 27 μg/mL; troponin <5 ng/mL was replaced with 1 ng/mL; BNP <10 pg/mL was replaced with 1 pg/mL. Blood test result values are reported as the nadir lymphocyte count, peak CRP, peak D-dimer, peak ferritin, peak troponin, peak BNP, peak creatinine and peak urea at each timepoint.

  • BNP = brain natriuretic peptide; CRP = C-reactive protein; DLCO = transfer factor for carbon monoxide; FEV1 = forced expiratory volume in 1 s; FVC = forced vital capacity; TLC = total lung capacity.