Prognostic impact of AF in HF: summary of observational studies
| Author | Setting | n | LVEF | Mean follow-up | %AF | Deaths, n (%) | p-value | |
|---|---|---|---|---|---|---|---|---|
| SR | AF | |||||||
| Middlekauff et al | HTx | 390 | <35% | 265 days | 19 | 123/315 (29) | 36/75 (48) | <0.005 |
| Stevenson et al | HTx | 750 | <40% | 2.0 years | 22 | 336/584 (45) | 104/160 (61) | <0.01 |
| Mahoney et al | HTx | 234 | <45% | 1.1 years | 27 | 26/171 (15) | 14/63 (22) | NS |
| Ahmed et al | Medicare Alabama | 944 | All | 4.0 years | 27 | 439/711 (62) | 166/233 (71) | <0.01 |
| Wojtkowska et al | Bilaystok, Poland | 120 | <30% | 3.0 years | 50 | 26/60 (43) | 33/60 (55) | NS |
| Corell et al | Danish HF clinic Network | 1,019 | <45% | 1.9 years | 26 | 180/750 (24) | 89/269 (33) | <0.05 |
| Pai and Varadarajan | Loma Linda VA | 8,931 | All | 2.5 years | 18 | 2164/7728 (28) | 529/1203 (44) | <0.0001 |
| Rivero-Ayerza et al | EuroHeart Failure Survey | 10,701 | All | N/A | 43 | 419/6027 (7) | 372/4674 (8) | <0.05 |
| Rusinaru et al | Somme< France | 368 | >50% | N/A | 36 | 125/236 (53) | 84/132 (64) | <0.05 |
| Hamaguchi et al | Japanese Registry data | 2,659 | All | 2.4 years | 35 | N/A | N/A | NS |
| Shotan et al | National HF Survey, Israel | 4,102 | All | 4 years | 33 | 1480/2734 (54.3) | 882/1359 (64.9) | 0.0001 |
AF = atrial fibrillation; HTx = heart transplantation; LVEF: left ventricular ejection fraction; NS = not significant; SR = sinus rhythm. Adapted with permission from Khan et al.7