Table 2.

Symptoms, signs and recommended diagnostic tests associated with PHI.

SymptomsSignsTestDifferential diagnosis
Fever, night sweats, general malaiseWeight loss, lymphadenopathyFBC, LFT, HIV antigen/antibody test, hepatitis A, B and C antibody, PCR, blood film, CRP, Paul Burnell EBV, CMV, HSVAcute infectious cause, depending on history, acute hepatitis A, B and C, CMV, EBV, tuberculosis, malaria glandular fever, lymphoma, leukaemia, malignancy
DiarrhoeaWeight lossStool MCS and OCP; infection screen as above; colonoscopy and biopsy if persistentInfectious diarrhoea inflammatory bowel disease
RashSTS, measles, rubellaSyphilis, measles, rubella, VZV *(depending on rash)
  • CMV = cytomegalovirus; CRP = C-reactive protein; EBV = Epstein–Barr virus; FBC = full blood count; HSV = herpes simplex virus; LFT = liver function test; MCS = microscopy, culture and sensitivities; OCP = ova, cysts and parasites; PCR = polymerase chain reaction; PHI = primary HIV infection; STS = syphilis serology; VZV = varicella zoster virus.