P2Y
12 binding | Irreversible | Irreversible | Reversible |
Indication | ACS treated medically or with PCI, ischaemic stroke, peripheral artery disease | ACS post PCI | ACS |
Dose | 300–600 mg loading75 mg maintenance | 60 mg loading dose, then 10 mg/day | 180 mg loading dose, then 90 mg bd |
| (5 mg if <60 kg) | |
Prodrug | Yes; needs hepatic metabolism | Yes; needs hepatic metabolism | No |
Onset of action | 2–8 hours | 30 min – 4 hours | 30 min – 4 hours |
Elimination time | 7–10 days | 7–10 days | 3–5 days |
CYP metabolism | CYP2C19 | CYP2C19 | CYP3A4/5 |
ACS = acute coronary syndrome; PCI = percutaneous coronary intervention. |