Without CVD | With CVD | ||
---|---|---|---|
High risk of CVD * | Very high risk of CVD ** | ||
Primary non-familial hypercholesterolaemia or mixed dyslipidaemia | Not recommended at any LDL-C concentration | Recommended only if persistent LDL-C >4.0 mmol/L | Recommended only if persistent LDL-C >3.5 mmol/L |
Primary heterozygous-familial hypercholesterolaemia | Recommended only if persistent LDL-C >5.0 mmol/L | Recommended only if persistent LDL-C >3.5 mmol/L | Recommended only if persistent LDL-C >3.5 mmol/L |
↵* High risk of cardiovascular disease is defined as a history of any of the following: acute coronary syndrome (such as myocardial infarction or unstable angina requiring hospitalisation), coronary or other arterial revascularisation procedures, chronic heart disease, ischaemic stroke, peripheral arterial disease.
↵** Very high risk of cardiovascular disease is defined as recurrent cardiovascular events or cardiovascular events in more than one vascular bed (ie polyvascular disease).
CVD = cardiovascular disease; LDL-C = low density lipoprotein cholesterol; PCSK9 = pro-protein convertase subtilisin kexin 9