Properties of non-vitamin K oral anticoagulants
| Dabigatran | Rivaroxaban | Apixaban | Edoxaban | |
|---|---|---|---|---|
| Mode of action | Direct thrombin inhibitor | Factor Xa inhibitor | Factor Xa inhibitor | Factor Xa inhibitor |
| Peak onset | 2 hours | 2–4 hours | 3–4 hours | 1–2 hours |
| Half-life | 12–14 hours | 5–13 hours | 8–15 hours | 10–14 hours |
| Elimination | 80% Renal | 66% Renal | 25% Renal | 50% Renal |
| 20% Biliary | 33% Biliary | 75% Biliary | 50% Biliary | |
| Adjust dose for renal failure | Yes avoid if eGFR <30 mL/min | Yes avoid if eGFR <30 mL/min | Yes avoid if eGFR <15 mL/min | Yes avoid if eGFR <15 mL/min |
eGFR = estimated glomerular filtration rate