Comparison of idiosyncratic DILI, ‘drug-induced’ autoimmune hepatitis and idiopathic autoimmune hepatitis46–49
| Idiosyncratic DILI | ‘Drug induced’ AIH | Idiopathic AIH | |
|---|---|---|---|
| Histology | Portal neutrophils, intracellular cholestasis | Interphase hepatitis, plasma cells | Interphase hepatitis, plasma cells, emperipolesis, rosettes |
| Rash, eosinophilia | +/− | +/− | - |
| Fibrosis | +/− | + | ++ |
| Response to steroids | - | + | + |
| Relapse on steroid withdrawal | - | +/− | + |
AIH = autoimmune hepatitis, DILI = drug-induced liver injury