ESCAPE | EXTEND-IA | MR CLEAN | REVASCAT | SWIFT PRIME | |
---|---|---|---|---|---|
Condition | Ischaemic stroke | Ischaemic stroke + thrombolysis | Ischaemic stroke | Ischaemic stroke + no or failed thrombolysis | Ischaemic stroke + thrombolysis |
Age, years | ≥18 | ≥18 | ≥18 | 18–85 | 18–80 |
Pre-morbid function | Barthel ≥90 | mRS ≤1 | - | mRS ≤1 | mRS ≤1 |
Time from onset, hours | <12 | <6 | <6 | <8 | <6 |
NIHSS | 5 | Any | ≥2 | >5 | ≥8 and <30 |
CT ASPECTS score5 | ≥6 | - | - | ≥7 | ≥6 |
Vessel occlusion | M1 ± ICA | ICA, M1 or M2 | ICA, M1, M2, A1 or A2 | ICA or M1 | ICA or M1 |
A1 = first part of anterior cerebral artery; A2 = second part of anterior cerebral artery; Barthel = Barthel Score; ICA = internal carotid artery; M1 = first part of middle cerebral artery; M2 = second part of middle cerebral artery; mRS = modified Rankin Score; NIHSS = National Institute of Health Stroke Score