Table 2.

Anti-fracture efficacy of drugs used in the treatment of osteoporosis in postmenopausal women

InterventionVertebral fracture (30–70% reduction)Non-vertebral fracture (15–20% reduction)Hip fracture (≤40% reduction)
Alendronate*+++
Ibandronate++**-
Risedronate*+++
Zoledronic acid*+++
Denosumab*+++
HRT+++
Raloxifene+NDND
Strontium ranelate*+++**
Teriparatide*++ND

  • ↵* also approved in men

  • ↵** post hoc analysis

  • HRT = hormone replacement therapy; ND = not determined