Newer medications on the horizon (further evidence needed)
Apremilast – phosphodiesterase-4 inhibitor18
Anakinra – interleukin (IL)-1 receptor antagonist19
Canakinumab – human monoclonal immunoglobulin G1 inhibitor of IL-1β20
Tocilizumab – IL-6 inhibitor21
Ustekinumab – IL-12/23 inhibitor22