Factors increasing the risk of relapse
| Clinical presentation | Serology | Treatment related |
|---|---|---|
| GPA | PR3-ANCA at presentation | Steroid withdrawal |
| ENT involvement | ANCA positive after induction | Immunosuppressive withdrawal |
| Better renal function (creatinine <200 μmol/L) | Rise in ANCA during treatment | Lower cumulative CYC exposure |
ANCA = antineutrophil cytoplasmic antibody; CYC = cyclophosphamide; ENT = ear, nose and throat; GPA = granulomatosis with polyangiitis; PR3 = proteinase 3