Box 3.

Prothrombotic conditions that need to be investigated in patients with portal vein thrombosis

  • JAK2 mutation

  • Factor V Leiden mutation

  • Prothrombin gene mutation

  • Antithrombin deficiency

  • Protein C and S deficiency

  • Antiphospholipid syndrome

  • Paroxysmal nocturnal haemoglobinuria

  • Vasculitis, including Behçet’s disease

  • Methylene tetrahydrofolate reductase and plasminogen activator inhibitor-type 1 gene mutations