Sepsis-3 definitions of sepsis and septic shocka
| Sepsis | Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection |
| Organ dysfunction is operationalised by an acute increase in SOFA score of ≥2 from the patient’s baseline level | |
| Septic shock | A subset of sepsis in which underlying circulatory and cellular and/or metabolic abnormalities are profound enough to substantially increase mortality |
| Shock is operationalised as persisting hypotension requiring vasopressors to maintain a mean arterial pressure ≥65 mmHg plus a lactate >2 mmol/L despite adequate fluid resuscitation |
↵aBased on Singer et al, 20162