Table 1.

Key pharmacokinetic features of common anticoagulant drugs

Name	Excretion	Plasma half-life
Warfarin	Hepatic metabolism to inactive metabolites excreted in urine	Effective half-life 40 h
UFH	Rapid endothelial cell internalisation (saturateable), slower renal clearance	45–90 min
LMWH	Predominantly renal	4 h
Fondaparinux	70% renal	17–21 h
Argatroban	Hepatic	45 min
Dabigatran	80% renal	13 h
Apixaban	25% renal, 75% hepatic	12 h
Edoxaban	35% renal, 65% hepatic	10–14 h
Rivaroxaban	25% renal, 75% hepatic	5–9 h