Key pharmacokinetic features of common anticoagulant drugs
Name | Excretion | Plasma half-life |
---|---|---|
Warfarin | Hepatic metabolism to inactive metabolites excreted in urine | Effective half-life 40 h |
UFH | Rapid endothelial cell internalisation (saturateable), slower renal clearance | 45–90 min |
LMWH | Predominantly renal | 4 h |
Fondaparinux | 70% renal | 17–21 h |
Argatroban | Hepatic | 45 min |
Dabigatran | 80% renal | 13 h |
Apixaban | 25% renal, 75% hepatic | 12 h |
Edoxaban | 35% renal, 65% hepatic | 10–14 h |
Rivaroxaban | 25% renal, 75% hepatic | 5–9 h |
LMWH = low-molecular-weight heparin; UFH = unfractionated heparin