Low-risk populations | Moderate / high-risk populations | |
---|---|---|
Major criteria | Migratory polyarthritis | Migratory polyarthritis/monoarthritis |
Carditis | Carditis | |
Chorea | Chorea | |
Erythema marginatum | Erythema marginatum | |
Subcutaneous nodules | Subcutaneous nodules | |
Minor criteria | Polyarthralgia | Monoarthralgia |
Fever ≥38.5°C | Fever ≥38.0°C | |
ESR ≥60 mm/hour and/or CRP ≥30 mg/L | ESR ≥30 mm/hour and/or CRP ≥30 mg/L | |
Prolonged PR interval on ECG | Prolonged PR interval on ECG | |
Evidence of GAS infection | Positive throat culture | |
Elevated/rising ASO titre | ||
Positive rapid streptococcal antigen test |
Low-risk population is defined as an ARF incidence ≤2 per 100,000 school-aged children or ≤1 per 1000 population per year. For a diagnosis, two major criteria or one major and two minor criteria must be fulfilled in the presence of a recent group A streptococcus (GAS) infection.4
ASO = antistreptolysin O; CRP = C-reactive peptide; ECG = electrocardiogram; ESR = erythrocyte sedimentation rate