Key clinical, test and implementation questions
| Clinical | How effective is FIT NPV as a rule out and can it be improved? |
| How often does FIT miss cancers? | |
| Can a risk score be derived using the PPV? | |
| Test | Is there a difference between the tests? |
| What are appropriate cut-off levels? | |
| What instructions should be given to patients and general practitioners? | |
| Implementation | Impact of FIT on endoscopic services? |
| Acceptability to general practitioners and patients? | |
| What are the barriers? |
FIT = faecal immunochemical test; NPV = negative predictive value; PPV = positive predictive value.